Related Experiment Video

Updated: Nov 12, 2025

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

22.0K

Genetic variation of RNF145 gene and blood lipid levels in Xinjiang population, China

Jing Ming1,2, Xian Wei1,2, Min Han1,2

  • 1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People's Republic of China.

Scientific Reports
|March 17, 2021
PubMed

Insights

Genetic variations in the RNF145 gene, specifically SNPs rs17056583 and rs12188266, are linked to cholesterol levels in the Xinjiang population. These findings may offer insights into managing dyslipidemia and coronary heart disease risk.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Biochemistry

Background:

  • Dyslipidemia is a primary risk factor for coronary heart disease (CHD).
  • The RNF145 gene encodes an E3 ubiquitin ligase crucial for cholesterol metabolism and hypercholesterolemia treatment.

Purpose of the Study:

  • To investigate the association between RNF145 gene polymorphisms and cholesterol levels in the Xinjiang, China population.

Main Methods:

  • Genetic analysis of 1396 participants from Xinjiang, China.
  • Genotyping of two RNF145 SNPs (rs17056583, rs12188266) using modified multiple connection detection response (iMLDR) technology.
  • Statistical analysis using general linear models, adjusting for confounding variables.

Main Results:

  • Both rs17056583 and rs12188266 were significantly associated with total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels (P < 0.001).
  • These associations remained significant after adjusting for factors like age, sex, smoking, obesity, and diabetes.
  • SNP rs17056583 also showed a significant association with high triglycerides concentrations.

Conclusions:

  • RNF145 gene SNPs rs17056583 and rs12188266 are significantly related to TC and LDL-C concentrations in the Xinjiang population.
  • These genetic variations may play a role in the development of dyslipidemia within this population.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.4K
Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats10:28

Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats

Published on: December 5, 2017

9.5K

Related Concept Videos

Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.8K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.3K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.3K
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
28.7K