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Exogenous ochronosis in the United States
N Lawrence1, C A Bligard, R Reed
1Department of Dermatology, Tulane University School of Medicine, New Orleans, LA.
Journal of the American Academy of Dermatology
|May 1, 1988
Summary
Hydroquinone bleaching creams can cause facial hyperpigmentation, leading to exogenous ochronosis. This rare condition involves skin darkening after initial lightening, as seen in two new cases.
Area of Science:
- Dermatology
- Toxicology
Background:
- Hydroquinone is a depigmenting agent used in skin lightening products.
- Adverse effects of hydroquinone, though rare, warrant investigation.
Observation:
- Two middle-aged Black women developed facial hyperpigmentation after using hydroquinone creams.
- Initial skin lightening was followed by progressive darkening in treated areas.
Findings:
- Biopsies confirmed exogenous ochronosis in both patients.
- These represent the fifth and sixth reported cases in the United States.
Implications:
- Highlights the potential for paradoxical hyperpigmentation from hydroquinone.
- Underscores the importance of monitoring for exogenous ochronosis with long-term use.