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Updated: Nov 12, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Deoxygenative C2-heteroarylation of quinoline N-oxides: facile access to α-triazolylquinolines
Geetanjali S Sontakke1, Rahul K Shukla1, Chandra M R Volla1
1Department of Chemistry, Indian Institute of Technology Bombay, Powai-400076, Mumbai, India.
Abstract:
A metal- and additive-free, highly efficient, step-economical deoxygenative C2-heteroarylation of quinolines and isoquinolines was achieved from readily available N-oxides and N-sulfonyl-1,2,3-triazoles. A variety of α-triazolylquinoline derivatives were synthesized with good regioselectivity and in excellent yields under mild reaction conditions. Further, a gram-scale and one-pot synthesis illustrated the efficacy and simplicity of the developed protocol. The current transformation was also found to be compatible for the late-stage modification of natural products.
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