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COVID-19 Antiviral and Treatment Candidates: Current Status

Erica Españo1, Dajung Kim1, Jiyeon Kim1

  • 1Department of Pharmacy, Korea University College of Pharmacy, Sejong 30019, Korea.

Immune Network
|March 17, 2021
PubMed

Insights

The COVID-19 pandemic requires new treatments. This review examines potential therapies targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and discusses ongoing clinical trial results.

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has had a profound global health and economic impact.
  • Existing vaccines are primarily for high-risk groups, leaving a need for effective COVID-19 treatments.
  • Accelerated drug discovery efforts are underway, exploring both repurposed and novel agents.

Purpose of the Study:

  • To review and stratify potential COVID-19 therapies based on their targets.
  • To discuss the current status and findings of clinical evaluations for these therapeutic candidates.

Main Methods:

  • Literature review of ongoing research and clinical trials for COVID-19 therapeutics.
  • Categorization of drug candidates by their mechanism of action or target in SARS-CoV-2 infection.
  • Synthesis of available data from clinical evaluations.

Main Results:

  • Several drug candidates targeting different stages of COVID-19 progression have been identified.
  • Ongoing clinical trials are evaluating the efficacy and safety of these agents.
  • Results from early-phase trials are beginning to emerge, informing further development.

Conclusions:

  • A diverse range of therapeutic strategies are being investigated for COVID-19 treatment.
  • Continued research and clinical evaluation are crucial to identify effective therapies.
  • Repurposed and novel agents hold promise for managing the COVID-19 pandemic.
Keywords:
Antiviral agentsCOVID-19Drug repositioningImmunotherapySevere acute respiratory syndrome coronavirus 2

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