Changes in Hematological Parameters and Liver Enzymes During Laparoscopic Cholecystectomy

Area of Science:

• Surgical Oncology
• Gastroenterology
• Hematology

Background:

• Laparoscopic surgeries are known to cause alterations in hematological parameters.
• Parameters like neutrophils, leukocytes, and platelet indices may change during these procedures.

Purpose of the Study:

• To evaluate the impact of laparoscopic cholecystectomy (LC) on hematological parameters and liver enzymes.
• To assess specific changes in blood counts and liver function tests before and after LC.

Main Methods:

• A prospective observational study was conducted on patients undergoing LC for symptomatic cholelithiasis.
• Hematological parameters and liver function tests were recorded preoperatively and postoperatively.
• A paired sample t-test was used to analyze the differences in mean values.

Main Results:

• Hemoglobin, hematocrit, platelets, and alkaline phosphatase showed a significant decrease postoperatively.
• Mean corpuscular volume, mean platelet volume, leukocytes, and alanine transaminase levels increased significantly after surgery.
• The observed changes in hemoglobin, MCV, Hct, leukocytes, MPV, and ALT were statistically significant (p<0.05).

Conclusions:

• Laparoscopic cholecystectomy leads to significant alterations in both hematological parameters and liver enzymes.
• These findings highlight the physiological response to the surgical procedure.