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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Nephrotic Syndrome I : Introduction01:24

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Vascular Spasm01:16

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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Updated: Nov 12, 2025

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Mononeuropathy multiplex associated with systemic vasculitis: A case report.

Hyun Jun Chae1, Jung Woo Kim1, Yae Lim Lee1

  • 1Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul 07061, South Korea.

World Journal of Clinical Cases
|March 17, 2021
PubMed
Summary

Systemic vasculitis can present with diverse symptoms, including nerve damage and organ complications. Early diagnosis and treatment are crucial for managing this challenging inflammatory condition.

Keywords:
Antiphospholipid syndromeCase reportMononeuropathiesPeripheral nervous system diseasesPulmonary embolismSystemic Vasculitis

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Area of Science:

  • Rheumatology
  • Neurology
  • Gastroenterology

Background:

  • Vasculitis involves systemic inflammation of blood vessel walls, leading to varied clinical presentations and diagnostic challenges.
  • This case highlights a rare presentation of systemic vasculitis with mononeuropathy multiplex and rectal perforation.

Observation:

  • A 61-year-old woman presented with myalgia, fever, and neurological deficits including foot drop and finger paresthesia.
  • Initial misdiagnosis as proctitis delayed appropriate treatment for vasculitis.
  • The patient developed sudden rectal perforation and pulmonary embolism during immunosuppressive therapy.

Findings:

  • Nerve conduction studies and sural nerve biopsy confirmed vasculitic neuropathy.
  • Laboratory findings suggested probable antiphospholipid syndrome (APS) co-occurring with vasculitis.
  • Treatment involved immunosuppression for vasculitis and anticoagulation for APS.

Implications:

  • This case underscores the importance of considering vasculitis in patients with unexplained systemic symptoms and neurological deficits.
  • Prompt recognition and multidisciplinary management are essential for patients with complex vasculitis presentations.
  • Co-occurrence of vasculitis and APS presents unique diagnostic and therapeutic challenges.