Related Experiment Video
Updated: Nov 12, 2025

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
Published on: August 1, 2025
T-Acute Lymphoblastic Leukemia Presenting as Bilateral Ovarian Mass in a Toddler
Sanjeev Khera1, Ankur Ahuja2, Arti Trehan2
1Department of Pediatrics, Army Hospital Research & Referral, Delhi Cantt, Delhi, 110010, India. kherakherakhera@gmail.com.
Abstract:
T-acute lymphoblastic leukemia (T-ALL) generally have nodal presentation while B-cell leukemia and lymphoma may have extra-nodal or visceral involvement. Intra-abdominal presentation of T-ALL is exceedingly rare. Bilateral ovarian involvement at the time of initial presentation of T-ALL has never been described in children, though it may be seen during relapses. The authors describe a toddler with T-ALL who presented with bilateral ovarian mass. Despite complete resolution of ovarian mass post-induction chemotherapy, minimum residual disease in bone marrow was high reaffirming aggressive nature of disease.

