Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus - A Case-control Study

Area of Science:

• Endocrinology
• Metabolic Disorders
• Reproductive Health

Background:

• Gestational diabetes mellitus (GDM) is a significant complication of pregnancy.
• Myonectin and irisin are myokines with potential roles in metabolic regulation.
• Understanding the involvement of myokines in GDM is crucial for early detection and management.

Purpose of the Study:

• To compare serum myonectin and irisin levels between pregnant women with and without GDM.
• To investigate the relationship between these myokines and metabolic parameters in GDM.

Main Methods:

• The study included 80 pregnant women (40 with GDM, 40 controls).
• Serum myonectin and irisin levels were quantified using the ELISA technique.
• Metabolic parameters, including glucose, insulin, HbA1c, and lipid profiles, were analyzed.

Main Results:

• Lower serum levels of myonectin and irisin were observed in the GDM group compared to controls.
• The GDM group exhibited higher age, BMI, gravida, parity, fasting glucose, fasting insulin, postprandial glucose, HbA1c, and HOMA-IR.
• HDL cholesterol was lower, and insulin resistance was significantly higher in women with GDM.

Conclusions:

• Myonectin and irisin levels are reduced in pregnant women with GDM.
• These findings indicate that myonectin and irisin may contribute to GDM pathogenesis.
• Myonectin and irisin show potential as novel biomarkers for gestational diabetes mellitus.