Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sharp mechanical tuning in a cochlear model without negative damping.

P J Kolston1

  • 1Department of Electrical and Electronic Engineering, University of Canterbury, Christchurch, New Zealand.

The Journal of the Acoustical Society of America
|April 1, 1988
PubMed
Summary

A new cochlear model demonstrates high mechanical response peaks without external energy input. Outer hair cell stereocilia stiffness suppresses motion, explaining cochlear structure and simulating real-world responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The importance of phase data and model dimensionality to cochlear mechanics.

Hearing research·2000
Same author

Comparing in vitro, in situ, and in vivo experimental data in a three-dimensional model of mammalian cochlear mechanics.

Proceedings of the National Academy of Sciences of the United States of America·1999
Same author

Finite element micromechanical modeling of the cochlea in three dimensions.

The Journal of the Acoustical Society of America·1996
Same author

A faster transduction mechanism for the cochlear amplifier?

Trends in neurosciences·1995
Same author

Hair cell based amplification in the cochlea.

Current opinion in neurobiology·1994
Same author

GABAB-mediated modulation of ionic conductances in type I hair cells isolated from guinea-pig semicircular canals.

Brain research·1993

Area of Science:

  • Auditory neuroscience
  • Bioacoustics
  • Biophysics

Background:

  • Conventional cochlear models require active negative damping or external energy to achieve specific mechanical response peaks.
  • Understanding the cochlea's mechanical response is crucial for diagnosing hearing loss and developing treatments.

Purpose of the Study:

  • To propose a novel cochlear model that generates high and wide mechanical response peaks without active negative damping.
  • To investigate the role of outer hair cell stereocilia stiffness in shaping the cochlear mechanical response.
  • To provide a potential explanation for structural differences in the basilar membrane and simulate cochlear responses.

Main Methods:

  • Development of a passive cochlear model incorporating outer hair cell stereocilia stiffness.

Related Experiment Videos

  • Simulation of mechanical responses based on the proposed model.
  • Comparison of simulated responses with in vivo and postmortem experimental data.

    • Main Results:

    • The model successfully generated arbitrarily high and wide mechanical response peaks without active negative damping.
    • Outer hair cell stereocilia stiffness was identified as the mechanism suppressing motion basal to the response peak.
    • Simulated responses closely matched experimentally measured in vivo and postmortem cochlear responses.

    Conclusions:

    • A passive mechanical model can replicate complex cochlear response profiles, challenging the necessity of active amplification in all models.
    • Outer hair cell stereocilia stiffness plays a significant role in tuning cochlear mechanics and may explain regional basilar membrane differences.
    • This model offers a new perspective on cochlear function and provides a valuable tool for auditory research.