Related Experiment Video

Updated: Nov 12, 2025

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

814

Simple heart rate and QT parameters during stress exercise testing to assess presence and severity of stable coronary

Murugaiyan Rajarajan1, Mugula Sudhakar Rao2, Padmakumar Ramachandran3

  • 1Consultant Cardiologist, Kumaran Medical Center, Kurumbapalayam, Coimbatore, Tamil Nadu, 641107, India.

Future Cardiology
|March 17, 2021
PubMed

Insights

Reduced heart rate and corrected QT interval recovery after exercise may predict coronary artery disease (CAD). This study found corrected QT variability correlated with CAD, but other parameters lacked diagnostic accuracy for disease severity.

Area of Science:

  • Cardiology
  • Clinical Electrophysiology

Background:

  • The link between QT prolongation and myocardial ischemia is established.
  • Limited research exists correlating corrected QT interval and heart rate recovery with coronary artery disease (CAD) severity.

Purpose of the Study:

  • To investigate the correlation between corrected QT interval, heart rate recovery, and the severity of coronary artery disease (CAD).

Main Methods:

  • A single-center, prospective, observational study.
  • Inclusion of 127 patients with CAD and 124 patients without CAD.

Main Results:

  • Corrected QT variability from peak to recovery showed a significant correlation with CAD (p=0.03).
  • Receiver operative characteristic analysis indicated no significant diagnostic accuracy for heart rate or QT parameters in predicting CAD presence or severity.

Conclusions:

  • Reduced heart rate rise from rest to peak exercise predicts CAD.
  • Impaired recovery of heart rate and corrected QT interval from peak exercise to 1-minute post-exercise also predicts CAD.

Keywords:
QT dispersionSYNTAX scoreheart rate recoverystable coronary artery diseasestress exercise testing

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