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Suppressive Myeloid Cells Shape the Tumor Immune Microenvironment.
Jia Xiong1,2, Hui Wang3, Qingqing Wang1,2
1Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Advanced Biology
|March 17, 2021
Summary
Tumor-infiltrating myeloid cells (TIMs) promote cancer growth and immune evasion by creating an immunosuppressive environment. Targeting these cells offers a promising strategy for effective cancer immunotherapy.
Area of Science:
- * Oncology
- * Immunology
- * Cancer Research
Background:
- * Cancer progression is influenced by the complex interactions within the tumor microenvironment (TME).
- * Tumor cells can evade immune surveillance through various mechanisms, including myeloid cell-mediated immunosuppression.
- * Tumor-infiltrating myeloid cells (TIMs) play a critical role in shaping the anti-tumor immune response.
Purpose of the Study:
- * To discuss the role of TIMs in tumor immune evasion.
- * To explore the potential of TIMs as therapeutic targets in cancer immunotherapy.
Main Methods:
- * Review of existing scientific literature on tumor-infiltrating myeloid cells.
- * Analysis of cellular and molecular mechanisms of immune evasion mediated by TIMs.
- * Discussion of current and future prospects for cancer immunotherapy targeting TIMs.
Main Results:
- * TIMs, once converted into immunosuppressive cells, accelerate tumor growth, angiogenesis, and metastasis.
- * TIMs contribute significantly to therapy resistance in various cancers.
- * Understanding TIMs' function is crucial for developing effective cancer treatments.
Conclusions:
- * TIMs are key players in promoting tumor immune evasion and progression.
- * Targeting TIMs represents a promising avenue for novel cancer immunotherapy strategies.
- * Further research into TIMs' biology may unlock new therapeutic opportunities.
Keywords:
cancer immunotherapyimmune escapeimmunoeditingtumor microenvironmenttumor-infiltrating myeloid cellsMore Related Videos
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