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Exploring dysregulated miRNAs in cryptorchidism: a systematic review

Hongshuai Jia1, Chunsheng Hao1

  • 1Department of Urology, Capital Institute of Paediatrics, Beijing, China.

The Journal of International Medical Research
|March 17, 2021
PubMed
Abstract

Insights

This study identified specific microRNAs (miRNAs) dysregulated in testicular tissues affected by cryptorchidism in both animal models and human patients. These findings suggest potential biomarkers for male infertility linked to this condition.

Area of Science:

  • Reproductive biology and molecular genetics.

Background:

  • Cryptorchidism, the failure of testes to descend, is a significant risk factor for male infertility.
  • MicroRNAs (miRNAs) are crucial regulators of gene expression and have been implicated in various biological processes, including testicular development and function.

Purpose of the Study:

  • To systematically identify and review dysregulated miRNAs in testicular tissues associated with cryptorchidism.
  • To explore potential miRNA biomarkers and therapeutic targets for cryptorchidism-related male infertility.

Main Methods:

  • Systematic literature search of databases for studies on miRNAs in cryptorchidism before May 2020.
  • Utilized TargetScan and Starbase to predict miRNA targets.
  • Performed Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analyses.

Main Results:

  • Five eligible publications were reviewed, analyzing 185 animal and human tissue samples.
  • Identified 21 differentially expressed miRNAs in cryptorchidism.
  • Three specific miRNAs (miR-210, miR-449a, miR-34c) were consistently dysregulated in both animal and human testicular tissues.

Conclusions:

  • Dysregulated miRNAs, particularly miR-210, miR-449a, and miR-34c, show promise as potential biomarkers for cryptorchidism.
  • Further investigation is needed to validate these miRNAs as diagnostic or therapeutic targets for male infertility associated with cryptorchidism.
Keywords:
CryptorchidismbiomarkersmiRNAsystematic review

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