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Related Experiment Video

Updated: Nov 12, 2025

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In-air particle generation by on-chip electrohydrodynamics.

Van T Dau1, Tung T Bui2, Canh-Dung Tran3

  • 1School of Engineering and Built Environment, Griffith University, Australia. v.dau@griffith.edu.au and Centre of Catalysis and Clean Energy, Griffith University, Australia.

Lab on a Chip
|March 17, 2021
PubMed
Summary

Dual electrospray generates charged nanoparticles for respiratory drug delivery. This innovative approach simplifies device manufacturing and enhances pulmonary nano-medicine delivery without external flow assistance.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Respiratory Medicine

Background:

  • Electrohydrodynamic atomization is a key technology for generating micro/nanoparticles for drug and antigen delivery.
  • Effective delivery of nanoparticles to the lungs remains a challenge in pulmonary medicine.

Purpose of the Study:

  • To present a novel dual-nozzle electrohydrodynamic atomization system for enhanced particle generation and delivery.
  • To explore the potential of this system for pulmonary nano-medicine applications.

Main Methods:

  • A conceptual design featuring two nozzles for dual electrospray.
  • Utilizing ionic wind generated by a direct current power source at chamfered tips.
  • Experimental validation using a prototype device.

Main Results:

  • Simultaneous generation and delivery of charged nanoparticles were achieved.
  • The generated mist of nanoparticles moved freely without external flow or collector restrictions.
  • The system demonstrated a simple design and manufacturing process.

Conclusions:

  • The dual electrospray system offers a promising, simplified approach for pulmonary nano-medicine delivery.
  • This technology facilitates the unrestricted migration of nanoparticle mists for respiratory treatments.
  • The design's simplicity is advantageous for developing new medical devices.