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Defining the underlying defect in insulin action in type 2 diabetes

Thiago M Batista1, Nida Haider1, C Ronald Kahn2

  • 1Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.

Diabetologia
|March 17, 2021
PubMed
Summary

Insulin resistance, a key defect in type 2 diabetes, involves complex molecular signaling in classical and non-classical tissues. Understanding cell-intrinsic and extrinsic factors is crucial for developing new therapies.

Keywords:
Cell-autonomousInsulin actionInsulin resistancePhosphorylationReviewThe metabolic syndromeTissue crosstalkType 2 diabetesiPS cells

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