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[Probiotic baths for atopic dermatitis].

Michaela Axt-Gadermann1, Krasimira Chudomirova2, Matthias Noll3

  • 1Integrative Gesundheitsförderung, Hochschule Coburg, Friedrich-Streib-Str. 2, 96450, Coburg, Deutschland. michaela.axt-gadermann@hs-coburg.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|March 17, 2021
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Summary
This summary is machine-generated.

Probiotic baths significantly improved atopic dermatitis (AD) symptoms and skin microbiome diversity. This supportive treatment reduced SCORAD scores and itching while decreasing Staphylococcus aureus.

Keywords:
DysbiosisMicrobiomePruritusStaphylococcal infectionsStaphylococcus aureus

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Area of Science:

  • Dermatology
  • Microbiology
  • Immunology

Background:

  • The skin microbiome's role in atopic dermatitis (AD) pathogenesis is increasingly recognized.
  • This presents opportunities for novel therapeutic interventions targeting microbial imbalances.

Purpose of the Study:

  • To evaluate the effectiveness of a probiotic bath additive on clinical symptoms and the skin microbiome in AD patients.
  • To assess changes in Staphylococcus aureus colonization and overall bacterial community richness.

Main Methods:

  • A randomized, double-blind study involving 22 AD patients using probiotic baths (4.5-9 × 10^9 CFU/liter) daily for 14 days.
  • Clinical symptoms were assessed using the SCORAD index and patient questionnaires.
  • Skin swabs were analyzed for Staphylococcus aureus quantitative PCR and microbiome composition via amplicon sequencing.

Main Results:

  • Both probiotic concentrations significantly reduced SCORAD scores and local SCORAD index values by day 14.
  • Patient-reported outcomes showed significant improvements in skin dryness and itching.
  • Mean Staphylococcus aureus gene copy number decreased by approximately 83%, with increased bacterial community richness observed.

Conclusions:

  • Topical probiotic baths are a promising supportive therapy for atopic dermatitis.
  • This treatment effectively alleviates skin barrier dysbiosis and reduces bacterial load.