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Updated: Nov 12, 2025
10:10
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
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[The role of citicoline in glaucoma]
Anselm G M Jünemann1, P Grieb2, R Rejdak3,2
1Department of General and Pediatric Ophthalmology Service, Medical University of Lublin, Chmielna 1 str., 20-079, Lublin, Polen. anselm.juenemann@outlook.de.
Summary
Citicoline demonstrates neuroprotective effects in glaucoma by preserving neuronal function and structure. This nootropic, taken orally, can improve cognitive function and quality of life in patients with open-angle glaucoma.
Area of Science:
- Neuroscience
- Ophthalmology
- Pharmacology
Background:
- Glaucoma involves neuronal degeneration throughout the visual pathway, including the retina, optic nerve, and brain.
- Understanding the full extent of neurodegeneration is crucial for developing effective treatments.
Purpose of the Study:
- To present the neuroprotective effects of citicoline and elucidate its mechanisms in glaucoma.
- To evaluate citicoline's potential as a therapeutic agent for glaucoma.
Main Methods:
- Review of experimental and clinical studies on citicoline in glaucoma.
- Analysis of neuroanatomical, neuroimaging, and pathogenetic data.
- Assessment of functional and morphological outcomes.
Main Results:
- Citicoline exhibits significant neuroprotective effects relevant to glaucoma pathogenesis.
- These effects are observable functionally and morphologically in open-angle glaucoma.
- Benefits, including improved cognitive performance and quality of life, are noted with oral citicoline (500-1000 mg/day) after approximately one year, independent of intraocular pressure, with no reported side effects.
Conclusions:
- Citicoline, a nootropic agent, offers a valuable addition to conventional glaucoma treatment.
- It presents a rational option for the prophylaxis and management of open-angle glaucoma.
- Its potential to enhance cognitive function may improve patient adherence and overall quality of life.
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