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COVID-19 pandemic: what about the gonads?
Alev Selek1, Metin Güçlü2, Şinasi Erol Bolu3
1Department of Endocrinology and Metabolism, Kocaeli University School of Medicine, Umuttepe, Kocaeli, Turkey. alevselek@gmail.com.
Hormones (Athens, Greece)
|March 17, 2021
Summary
This review explores how COVID-19 impacts male and female gonads, affecting sex steroids and fertility. It examines underlying mechanisms and potential treatments for this significant health concern.
Area of Science:
- Reproductive Medicine
- Infectious Diseases
- Endocrinology
Background:
- The novel coronavirus (SARS-CoV-2) has caused a global pandemic with significant health implications.
- The gonads are potential targets of COVID-19, influencing disease severity and potentially impacting reproductive health.
- Observed differences in COVID-19 clinical presentation between genders suggest underlying biological and behavioral factors.
Purpose of the Study:
- To review the potential mechanisms by which COVID-19 affects the gonads in both sexes.
- To explore the impact of COVID-19 on sex steroids, fertility, and gonadal function.
- To discuss emerging treatment strategies for COVID-19 related gonadal dysfunction.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of genetic, hormonal, immunological, and behavioral factors.
- Synthesis of evidence on COVID-19's effects on gonadal function.
Main Results:
- COVID-19 may affect gonadal function through various pathways, including direct viral invasion and inflammatory responses.
- Differences in genetic, hormonal, and lifestyle factors contribute to gender-specific COVID-19 outcomes and potential gonadal impact.
- Evidence suggests potential impacts on sex hormone production and fertility, though further research is needed.
Conclusions:
- Understanding the intricate relationship between COVID-19 and the gonads is crucial for comprehensive patient care.
- Further research is warranted to elucidate the precise mechanisms and long-term consequences.
- Investigating novel therapeutic approaches may mitigate adverse effects on reproductive health.
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