Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimation of postmortem interval based on the third component of complement (C3) cleavage.

Y Kominato1, S Harada, K Yamazaki

  • 1Department of Legal Medicine, University of Tsukuba, Japan.

Journal of Forensic Sciences
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical strategy for pheochromocytoma: emphasis on the pledge of flank extraperitoneal approach in selected patients.

Surgery·1995
Same author

Screening for apoptosis inducers in microbial products and induction of apoptosis by cytostatin.

The Journal of antibiotics·1995
Same author

[Ubiquitin immunoreactivity in the central nervous system of gracile axonal dystrophy (GAD) mouse].

No to shinkei = Brain and nerve·1995
Same author

Stimulation by thyroid-stimulating hormone and Grave's immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and flt mRNA expression in the rat thyroid in vivo.

The Journal of clinical investigation·1995
Same author

Assessment of spine bone mineral density in ovariectomized rats using DXA.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·1995
Same author

A study of intercellular relationships between trabecular bone and marrow stromal cells in the murine femoral metaphysis.

Anatomy and embryology·1995
Same journal

GenoEye: A machine learning-based framework for the prediction of intermediate eye color phenotypes.

Journal of forensic sciences·2026
Same journal

Sharp force trauma analysis without animal bones: A proposal for sustainable and ethical bone proxies.

Journal of forensic sciences·2026
Same journal

Absolute dating of modern paper using <sup>14</sup>C bomb peak data of the paper fibers.

Journal of forensic sciences·2026
Same journal

Forensic timeline investigation of Apple Health app on iOS.

Journal of forensic sciences·2026
Same journal

Help v. harm: How a "lookup table" for evaluating DNA evidence given activity-level propositions could lead to wrongful convictions.

Journal of forensic sciences·2026
Same journal

Correction to "Development and Evaluation of an Iodoplatinate-Based Strip-Type Kit for On-Site Drug Screening in Beverages".

Journal of forensic sciences·2026
See all related articles

Forensic scientists can estimate the postmortem interval (PMI) by measuring the conversion of the third component of complement (C3) in blood. Higher temperatures accelerate C3 cleavage, correlating directly with time since death.

Area of Science:

  • Forensic Science
  • Biochemistry
  • Immunology

Background:

  • Accurate estimation of postmortem interval (PMI) is crucial in forensic investigations.
  • The third component of complement (C3) undergoes spontaneous degradation after death.

Purpose of the Study:

  • To investigate the potential of C3 degradation in whole blood as a biomarker for estimating PMI.
  • To establish a correlation between C3 cleavage and time since death.

Main Methods:

  • Whole blood samples were analyzed using crossed immunoelectrophoresis.
  • In vitro experiments assessed C3 cleavage at varying temperatures.
  • Cadaveric blood samples were analyzed to correlate C3 cleavage with known PMI.

Main Results:

Related Experiment Videos

  • C3 cleavage (conversion of native C3 to C3c) was observed to be temperature-dependent in vitro.
  • A significant positive correlation was found between the percentage of C3 cleavage and PMI in cadaveric blood.

Conclusions:

  • The ratio of C3 cleavage in blood can be utilized to estimate the postmortem interval.
  • This method offers a potential new tool for forensic analysis in determining time since death.