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Peripapillary hyperreflective ovoid mass-like structures (PHOMS) in children.
Ye Jin Ahn1, Yoo Yeon Park1, Sun Young Shin2
1Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Eye (London, England)
|March 18, 2021
Summary
Children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) have smaller scleral canals and may have buried optic disc drusen. Large PHOMS are associated with reduced optic disc vessel density.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Optical Coherence Tomography (OCT) Imaging
Background:
- Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are observed in children.
- The structural characteristics and vascularity of PHOMS in pediatric eyes require further investigation.
Purpose of the Study:
- To analyze structural characteristics and perifoveal/peripapillary vasculature using OCT in children with PHOMS.
- To compare these findings with those in normal pediatric subjects.
Main Methods:
- Spectral domain-OCT and swept-source OCT were used to evaluate 45 children (84 eyes) with blurry disc margins.
- Patients were grouped based on the presence and size of PHOMS, excluding eyes with visible optic disc drusen (ODD).
- Foveal avascular zone (FAZ) and vessel densities in the macula and optic disc area were assessed, along with peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell and inner plexiform layer (mGCIPL) thickness.
Main Results:
- Eyes with PHOMS sometimes exhibited coexisting buried ODD.
- A significantly smaller scleral canal diameter was found in PHOMS-positive eyes compared to controls.
- Reduced vessel density in the papillary, peripapillary, and optic nerve head regions was observed in the large PHOMS group compared to controls.
Conclusions:
- Children with PHOMS possess smaller scleral canals and may have associated buried ODD.
- Significant reductions in optic disc area vessel density are noted in children with large PHOMS compared to healthy controls.
