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Updated: Nov 12, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Pathologically Relevant Mouse Models for Epstein-Barr Virus-Associated B Cell Lymphoma.

Shiyu Huang¹, Tomoharu Yasuda¹

¹Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Frontiers in Immunology

|March 18, 2021

Summary

Epstein-Barr virus (EBV) can cause B cell transformation and lymphoproliferative diseases, particularly under immune suppression. Mouse models help study EBV lymphomagenesis and immune surveillance for new therapies.

Keywords:

B cell lymphoma Epstein-Barr virus immune surveillance lymphoproliferative disease mouse model

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Area of Science:

Immunology
Virology
Oncology

Background:

Epstein-Barr virus (EBV) is a common human herpesvirus.
EBV infects B cells and can cause their transformation.
Immune suppression can lead to EBV-driven lymphoproliferative diseases and lymphomas.

Purpose of the Study:

To summarize EBV products implicated in tumorigenesis.
To review EBV-associated lymphomas.
To discuss relevant preclinical mouse models for EBV-associated diseases.

Main Methods:

Literature review of EBV tumorigenesis.
Analysis of EBV-associated lymphoma data.
Evaluation of preclinical mouse models in EBV research.

Main Results:

Identified key EBV products contributing to B cell transformation and lymphomagenesis.
Detailed the spectrum of EBV-associated lymphomas.
Highlighted the utility of mouse models in studying disease mechanisms.

Conclusions:

EBV plays a critical role in lymphomagenesis, especially in immunocompromised individuals.
Understanding EBV's oncogenic products and immune surveillance is crucial.
Preclinical mouse models are valuable tools for developing novel therapeutic strategies against EBV-associated cancers.