Related Experiment Video

Updated: Nov 12, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

837

Interaction Between LncRNA and UPF1 in Tumors

Junjian He1,2, Xiaoxin Ma1,2

  • 1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Frontiers in Genetics
|March 18, 2021
PubMed

Insights

Long non-coding RNAs (LncRNAs) interacting with UPF1, a key RNA decay factor, are implicated in tumor development. This interaction provides a basis for cell transformation and tumorigenic growth, highlighting a novel area in cancer research.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (LncRNAs) regulate gene expression through interactions with proteins and other RNAs.
  • UPF1 is a crucial RNA-binding protein involved in RNA decay pathways, with dysregulated expression observed in various tumors.
  • RNA decay pathways are essential for controlling cellular RNA levels.

Purpose of the Study:

  • To review the existing evidence on the interaction between fourteen specific lncRNAs and the UPF1 protein.
  • To explore the role of lncRNA-UPF1 interactions in the context of tumor development and progression.

Main Methods:

  • Literature review of studies investigating lncRNA and UPF1 interactions.
  • Analysis of data linking lncRNA-UPF1 complexes to tumorigenesis.

Main Results:

  • Evidence from fourteen lncRNAs demonstrating their interaction with UPF1.
  • UPF1's involvement in RNA decay pathways is linked to its interactions with specific lncRNAs.

Conclusions:

  • The interaction between lncRNAs and UPF1 is a fundamental mechanism contributing to cell transformation.
  • These interactions play a significant role in promoting tumorigenic growth, suggesting potential therapeutic targets.
Keywords:
LncRNA – long non-coding RNARBPUPF1post-transcriptional regulation of gene expressiontumor

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.1K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
11.2K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.5K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.4K