Related Experiment Video
Updated: Jun 23, 2026

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
Published on: February 24, 2023
Subacromial pigmented villonodular synovitis: case report and review
Vitor Luis Pereira1, Arthur Rodrigues Baldan1, Carlos Vicente Andreoli1
1Traumatology Sports Center (CETE), (DOT-UNIFESP/EPM), Orthopedics and Traumatology Department of the Escola Paulista de Medicina, Federal University of São Paulo São Paulo, SP, Brazil.
Pigmented villonodular synovitis (PVNS) is a rare condition affecting synovial tissue. This case highlights successful surgical treatment of shoulder PVNS in a young patient, emphasizing complete removal of pathological tissue.
Area of Science:
- Orthopedics
- Radiology
- Pathology
Background:
- Pigmented villonodular synovitis (PVNS) is a benign proliferative condition of synovial tissue.
- It typically affects joints, tendon sheaths, and bursae, usually in young to middle-aged adults.
- Shoulder PVNS, particularly in the subacromial bursa without joint involvement, is exceptionally rare.
Observation:
- A 15-year-old patient presented with a 2-year history of symptomatic PVNS in the subacromial bursa.
- Magnetic resonance imaging (MRI) was crucial for diagnosis, surgical planning, and monitoring.
- The patient experienced exuberant symptoms, necessitating intervention.
Findings:
- Complete surgical synovectomy was performed to remove all affected synovial tissue.
- The patient achieved good clinical results at the 1-year follow-up post-surgery.
- Early and complete excision is vital to prevent joint destruction.
Implications:
- This case underscores the importance of considering PVNS in the differential diagnosis of shoulder pain, even in younger individuals.
- Effective management relies on accurate diagnosis via advanced imaging and thorough surgical resection.
- Prompt treatment can lead to favorable outcomes and preserve joint function.
Related Concept Videos
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management
Acute Pyelonephritis II: Diagnostic Studies and Management
Acute Pancreatitis I: Introduction

