Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered serotonin uptake kinetics in multiple sclerosis.

M Markianos1, C Sfagos

  • 1Psychiatry Clinic, Athens University Medical School, Eginition Hospital, Greece.

Journal of Neurology
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Higher Orexin A levels in lumbar compared to ventricular CSF: a study in idiopathic normal pressure hydrocephalus.

Peptides·2013
Same author

Elevated CSF serotonin and dopamine metabolite levels in overweight subjects.

Obesity (Silver Spring, Md.)·2013
Same author

The notion of "Sisyphus task" in medicine: A reconstruction.

Psychiatrike = Psychiatriki·2012
Same author

Neuromyelitis optica spectrum disease with positive autoimmune indices: a case report and review of the literature.

Case reports in medicine·2011
Same author

Prolactin and cortisol responses to acute intravenous clomipramine challenge in patients with mania, depression and healthy controls: evidence for reduced serotonergic responsivity.

Neuropsychobiology·2010
Same author

The onset of multiple sclerosis in Greece: a single-center study of 1,034 consecutive patients.

European neurology·2010

Platelet serotonin uptake is altered in multiple sclerosis (MS) patients during relapse. A competitive block of serotonin uptake sites may contribute to MS pathophysiology, correlating with disability progression.

Area of Science:

  • Neuroscience
  • Hematology
  • Pharmacology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
  • Serotonin is a neurotransmitter implicated in various neurological functions.
  • Platelets are increasingly recognized for their role in inflammatory and neurological conditions.

Purpose of the Study:

  • To investigate platelet serotonin uptake kinetics in patients with multiple sclerosis (MS) during acute relapse.
  • To determine if alterations in serotonin uptake correlate with disease severity in MS.

Main Methods:

  • Studied platelet serotonin uptake in 20 MS patients in acute relapse.
  • Compared uptake parameters (maximum velocity and Michaelis constant) with 20 age- and sex-matched healthy controls.

Related Experiment Videos

  • Correlated kinetic parameters with the Multiple Sclerosis Severity Score (MSDS).

    • Main Results:

    • No significant difference was observed in the maximum velocity of serotonin uptake between MS patients and controls.
    • Michaelis constants for serotonin uptake were significantly higher in MS patients compared to controls.
    • Higher Michaelis constants positively correlated with higher Disability Status Scale scores in MS patients.

    Conclusions:

    • Results suggest a competitive blockade of serotonin uptake sites on platelets in MS patients.
    • This platelet serotonin dysregulation may be linked to MS pathophysiology and disease progression.
    • Platelet serotonin transport could represent a potential biomarker or therapeutic target in multiple sclerosis.