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Updated: Nov 12, 2025
Use of a Rat Model to Study Ventral Abdominal Hernia Repair
Published on: October 2, 2017
Lichtenstein inguinal hernia repairs with porcine small intestine submucosa: a 5- year follow-up. a prospective
Baoshan Li1, Xin Zhang1, Yi Man1
1Department of Hernia and Abdominal Wall Surgery, Tianjin Union Medical Center, 190, jieyuan Road, HongqiaoDistrict, Tianjin 300121, China.
Insights
Porcine small intestine submucosa (SIS) patches demonstrate safety and efficacy in long-term inguinal hernia repair. This study found low recurrence and complication rates, supporting SIS patch use in Lichtenstein repair.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Gastroenterology
Background:
- Porcine small intestine submucosa (SIS) biologic patches are utilized in inguinal hernia repair.
- Limited data exist on the long-term outcomes of SIS patch use in this context.
Purpose of the Study:
- To investigate the long-term effects and efficacy of SIS patches in open inguinal hernia repair.
- To compare the outcomes of SIS patch repair with a control group over an extended follow-up period.
Main Methods:
- A cohort of 76 patients with unilateral inguinal hernias underwent Lichtenstein tension-free repair.
- Patients received either an SIS patch (Beijing Datsing Bio-Tech Co., Ltd.) or a Surgisis patch (COOK, USA).
- Long-term follow-up (>5 years) was conducted on 66 patients (86.8% follow-up rate).
Main Results:
- One recurrence and one case of chronic pain were observed in the control group.
- No statistically significant differences (P > 0.05) were found between groups regarding recurrence, chronic pain, foreign body sensation, or infection.
- The SIS patch group exhibited a low recurrence and complication rate.
Conclusions:
- The porcine small intestine submucosa (SIS) biologic patch is a safe and effective option for inguinal hernia Lichtenstein repair.
- Long-term observations indicate favorable outcomes with low rates of recurrence and complications.
Abstract:
Porcine small intestine submucosa (SIS) biologic patch has been used in inguinal hernia repair. However, there are little data available to assess the long-term effect after repair. This study aimed to explore the long-term effect of SIS patch in open inguinal hernia repair. Sevent-six patients with unilateral inguinal hernia were treated with Lichtenstein tension-free hernia repair using SIS patch (Beijing Datsing Bio-Tech Co., Ltd.) and Surgisis patch (COOK, USA) in Tianjin Union Medical Center and China-Japan Friendship Hospital. In the trial, the long-term efficacy of the treatment group and the control group were compared. A total of 66 patients in both groups received long-term follow-up (> 5 years) after surgery, with a follow-up rate of 86.8%. During the follow-up period, there was one case of recurrence, one case of chronic pain in the control group. There was no statistically significant difference (P > 0.05) in terms of recurrence, chronic pain, foreign body sensation and infection between the two groups of patients. After long-term observations, it has been found that the porcine small intestinal submucosa (SIS) biological patch is safe and effective for inguinal hernia Lichtenstein repair, and has a low recurrence rate and complication rate.
