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Updated: Nov 12, 2025

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines
Published on: October 11, 2022
Rickettsial neuroretinitis: A report of 2 cases
Caroline C Awh1, Akshay S Thomas2
1UH Regional Hospitals, 27100 Chardon R, Richmond Heights, OH, 44143, USA.
Purpose:
The authors present two cases of neuroretinitis caused by Rickettsia rickettsii infection.
Observations:
Case 1 is a 24-year-old male who presented with 2 months of vision loss. Case 2 is a 38-year-old female who presented with 4 weeks of eye pain and vision loss. Examination of both patients revealed neuroretinitis characterized by optic disc swelling with macular exudates, and subsequent serological analysis was positive for Rickettsia rickettsii. Both patients responded favorably to treatment with oral doxycycline and prednisone.
Conclusions And Importance:
Given the potential for neuroretinitis to cause permanent vision loss, the presence of acute vision loss, optic disc edema, and macular exudates should prompt an evaluation for Rickettsial disease in endemic areas, even in the absence of systemic symptoms or known history of a tick bite.

