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Updated: Nov 12, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD
Mark D McCauley1,2, Jesse Y Hsu3, Ana C Ricardo1
1Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
In adults with chronic kidney disease (CKD), new-onset atrial fibrillation (AF) did not significantly impact cognitive function decline over time. This study examined the relationship between AF and cognitive changes in individuals with CKD.
Area of Science:
- Nephrology
- Cardiology
- Neurology
Background:
- Atrial fibrillation (AF) is linked to cognitive decline in the general population.
- The association between AF and cognitive function in chronic kidney disease (CKD) patients remains understudied.
Purpose of the Study:
- To investigate the relationship between incident AF and cognitive function changes in adults with CKD.
Main Methods:
- A subgroup of 3254 adults from the Chronic Renal Insufficiency Cohort Study was analyzed.
- Incident AF was identified via ECG or hospitalization records.
- Cognitive function was assessed biennially using the Modified Mini-Mental State Exam.
- Linear mixed effects regression models were employed to analyze the data.
Main Results:
- Individuals with incident AF were older, had more cardiovascular disease and hypertension, and lower eGFR.
- After a median follow-up of 6.8 years, no significant association was found between incident AF and cognitive function decline.
- The study included 96 individuals with incident AF and 3158 without.
Conclusions:
- In adults with CKD, incident AF is not associated with a decline in cognitive function.
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