Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

143
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
143
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

167
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
167
Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

234
Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
234
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

351
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
351
Improving Translational Accuracy02:07

Improving Translational Accuracy

12.2K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
12.2K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.3K
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PURE: policy-guided unbiased REpresentations for structure-constrained molecular generation.

Journal of cheminformatics·2025
Same author

A drop-out mechanism for active learning based on one-attribute heuristics.

Frontiers in artificial intelligence·2025
Same author

Causal contextual bandits with one-shot data integration.

Frontiers in artificial intelligence·2024
Same author

Active learning with human heuristics: an algorithm robust to labeling bias.

Frontiers in artificial intelligence·2024
Same author

Hypergraph partitioning using tensor eigenvalue decomposition.

PloS one·2023
Same author

A deep network-based model of hippocampal memory functions under normal and Alzheimer's disease conditions.

Frontiers in neural circuits·2023
Same journal

Logic, inference, understanding: cross-domain generalization for generative language models.

Frontiers in artificial intelligence·2026
Same journal

Label tree semantic losses for rich multi-class medical image segmentation.

Frontiers in artificial intelligence·2026
Same journal

Score-based generative diffusion models to synthesize full-dose FDG brain PET from MRI in epilepsy patients.

Frontiers in artificial intelligence·2026
Same journal

Resource-efficient retrieval-augmented question answering for the Indian Lok Sabha dataset.

Frontiers in artificial intelligence·2026
Same journal

Violation detection in power operation sites based on multi-scale detection and few-shot learning.

Frontiers in artificial intelligence·2026
Same journal

Deep reinforcement learning-based reversible medical image encryption framework for secure IoMT environments.

Frontiers in artificial intelligence·2026
See all related articles

Related Experiment Video

Updated: Nov 12, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

878

Interpretability With Accurate Small Models.

Abhishek Ghose1, Balaraman Ravindran2

  • 1Department of Computer Science and Engineering, IIT Madras, Chennai, India.

Frontiers in Artificial Intelligence
|March 18, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a novel technique to create accurate, small machine learning models by optimizing the training data distribution. This approach balances model interpretability and classification accuracy effectively.

Keywords:
Bayesian optimizationMLdensity estimationinfinite mixture modelsinterpretable machine learning

More Related Videos

Analyzing Mitochondrial Morphology Through Simulation Supervised Learning
12:06

Analyzing Mitochondrial Morphology Through Simulation Supervised Learning

Published on: March 3, 2023

4.4K
Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

1.5K

Related Experiment Videos

Last Updated: Nov 12, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

878
Analyzing Mitochondrial Morphology Through Simulation Supervised Learning
12:06

Analyzing Mitochondrial Morphology Through Simulation Supervised Learning

Published on: March 3, 2023

4.4K
Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

1.5K

Area of Science:

  • Machine Learning
  • Artificial Intelligence
  • Data Science

Background:

  • Interpretable models are crucial but often less accurate than larger ones.
  • Constraining model size (e.g., decision tree depth) typically reduces classification accuracy.
  • A trade-off exists between model interpretability and predictive performance.

Purpose of the Study:

  • To present a practical technique for minimizing the trade-off between interpretability and classification accuracy.
  • To enable arbitrary learning algorithms to produce highly accurate, small-sized models.
  • To identify optimal training data distributions for a given model size.

Main Methods:

  • Representing training distributions as combinations of sampling schemes, each defined by a parameterized probability mass function.
  • Utilizing an Infinite Mixture Model with Beta components to represent the combination of sampling schemes.
  • Employing Bayesian Optimization to learn mixture model parameters, reducing optimization variables to a fixed set of eight.

Main Results:

  • Significantly reduced the number of variables needed for distribution optimization from O(d) to a fixed set of eight.
  • Demonstrated effectiveness across decision trees, linear probability models, and gradient boosted models on real-world datasets.
  • Achieved significant F1-score improvements, exceeding 100% in some cases.

Conclusions:

  • The proposed model-agnostic technique effectively balances interpretability and accuracy for various model families.
  • This method offers a flexible and efficient approach to generating high-performance, interpretable machine learning models.
  • The technique requires relatively cheap preprocessing and yields substantial performance gains.