Related Experiment Video
Updated: Nov 12, 2025
04:48
Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
Published on: March 24, 2022
3.5K
Host-Guest Interaction-Mediated Photo/Temperature Dual-Controlled Antibacterial Surfaces
Yifeng Ni1, Dong Zhang2, Yang Wang1
1College of Materials Science & Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
ACS Applied Materials & Interfaces
|March 18, 2021
Summary
This study introduces a novel dual-controlled antibacterial surface that prevents bacterial attachment and kills bacteria. The smart surface can be regenerated on-demand, offering a promising platform for biomedical applications.
Area of Science:
- Materials Science
- Biomedical Engineering
- Polymer Chemistry
Background:
- Bacterial attachment and colonization on surfaces pose significant challenges in healthcare settings.
- Developing surfaces with on-demand regeneration capabilities for antibacterial applications remains a critical unmet need.
Purpose of the Study:
- To engineer a smart, dual-controlled antibacterial surface utilizing host-guest interactions.
- To achieve on-demand regeneration and successive antimicrobial functions for renewable antibacterial surfaces.
Main Methods:
- Topological combination of stimuli-responsive polymers (poly(2-hydroxyethyl methacrylate) and poly(N-isopropylacrylamide)) with nanobactericide.
- Integration of azobenzene/cyclodextrin (Azo/CD) host-guest complex for controlled release.
- Utilizing photo (UV light) and temperature stimuli for surface control.
Main Results:
- The developed surface demonstrated significant resistance to initial bacterial attachment (∼84.9%).
- It effectively killed inevitable bacteria attacks (∼93.2%).
- Over 94.9% of killed bacteria were released on-demand, even after three cycles, showcasing regenerative capability.
Conclusions:
- The novel surface exhibits triple successive antimicrobial functions: resistance, killing, and on-demand release.
- This research presents a promising strategy for developing renewable antibacterial surfaces.
- The developed platform holds potential for various biomedical and surgical applications.
Related Concept Videos
01:23Physical Methods for Controlling Microbial Growth: Temperature
694
Heat is a widely used method to control microbial growth by targeting and denaturing cellular proteins, thereby killing or inactivating microbes. This method's effectiveness is quantified using parameters such as the thermal death point (TDP), thermal death time (TDT), and decimal reduction time (D value). TDP represents the lowest temperature at which all microorganisms in a liquid suspension are eliminated within 10 minutes, whereas TDT is the time necessary to achieve sterilization at a...
694
01:23Hand hygiene
5.0K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
5.0K
01:18Surface Membrane Barriers
2.0K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
2.0K
01:26Physical Methods for Controlling Microbial Growth: Radiation and Filtration
718
Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.
718
01:29Methods for Controlling Microbial Growth
1.1K
Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
1.1K
01:14Assessing Body Temperature - Oral
1.1K
Here are the steps to accurately measure oral temperature using an electronic thermometer:
Step 1:
Start by practicing proper hand hygiene to prevent the spread of microorganisms.
Step 2:
Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
Step 3:
Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
Step 4:
Instruct the patient to open their mouth and place...
Step 1:
Start by practicing proper hand hygiene to prevent the spread of microorganisms.
Step 2:
Take the thermometer out of the charging unit, switch it on, and wait for the ready sign.
Step 3:
Gently slide the probe cover until a click is heard. This simple action prevents cross-contamination and ensures the correct placement of the probe cover.
Step 4:
Instruct the patient to open their mouth and place...
1.1K