Related Experiment Video
Updated: Nov 12, 2025
04:37
Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
1.0K
Nitrofurantoin-Associated Acute Granulomatous Interstitial Nephritis
B K Anupama1, Parth Sampat1, Harvir S Gambhir1
1SUNY Upstate Medical University, Syracuse, NY, USA.
Journal of Investigative Medicine High Impact Case Reports
|March 18, 2021
Summary
Nitrofurantoin can cause acute granulomatous interstitial nephritis, a rare kidney injury. Discontinuation of the drug and corticosteroids improved renal function in a patient with this condition.
Area of Science:
- Nephrology
- Pharmacology
- Pathology
Background:
- Nitrofurantoin is a common antibiotic used for urinary tract infections.
- Acute kidney injury (AKI) is a potential adverse effect of certain medications.
- Interstitial nephritis is an inflammatory condition affecting the kidney tubules and interstitium.
Observation:
- A 71-year-old female presented with incidental nonoliguric acute kidney injury during evaluation for visual hallucinations.
- The patient had inadvertently taken nitrofurantoin for three months.
- Renal biopsy revealed acute granulomatous interstitial nephritis.
Findings:
- The patient's renal function improved significantly after discontinuing nitrofurantoin.
- Corticosteroid administration further aided in the recovery of renal function.
- This case highlights a rare association between nitrofurantoin and acute granulomatous interstitial nephritis.
Implications:
- Clinicians should consider nitrofurantoin-induced interstitial nephritis in patients presenting with unexplained AKI.
- Early recognition and drug withdrawal are crucial for managing this adverse drug reaction.
- This case contributes to the understanding of rare renal complications associated with nitrofurantoin therapy.
Keywords:
acute interstitial nephritisacute kidney injurygranulomatous interstitial nephritisnitrofurantoinMore Related Videos
07:38Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
8.6K
17:13Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Published on: April 28, 2013
17.3K
Related Concept Videos
01:29Acute Kidney Injury II: Pathophysiology
514
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
514
01:27Acute Pyelonephritis I: Introduction
199
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
199
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
118
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
118
01:10Nephrons
4.8K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
4.8K
01:24Nephrotic Syndrome I : Introduction
254
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
254
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
130
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
130