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Updated: Nov 12, 2025

Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow
Published on: January 13, 2017
Highly oxygenated ent-atisane and podocarpane diterpenoids from Excoecaria agallocha
Guangyan Liu1,2, Zhisen Zhang3, Yuanhao Wang1,2
1Guangxi Key Laboratory of New Energy and Building Energy Saving, Guilin University of Technology, Guilin, China.
Abstract:
A new highly oxygenated ent-atisane diterpenoid, namely excagallonoid A (1), together with five known analogues (2 - 6) were isolated from the leaves and twigs of Excoecaria agallocha. Their structures were elucidated on the basis of extensive spectroscopic analyses (HRESIMS, UV, IR, 1 D and 2 D NMR), and the absolute configurations of 1 and 5 were determined by single-crystal X-ray diffraction. Compound 1 represents the first example of an ent-atisane diterpenoid featuring a vicinal 2,3-diol moiety. Compounds 1 and 4 exhibited weak cytotoxicities in vitro against RKO colon cancer cells with IC50 values of 28.7 ± 1.98 and 32.6 ± 2.81 µM, respectively.
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