Immunomodulators in newly diagnosed multiple myeloma: current and future concepts
Michel Delforge1, Sophie Vlayen2, Nicolas Kint1
1Department of Hematology, University of Leuven and Leuven Cancer Institute, Leuven, Belgium.
Expert Review of Hematology
|March 18, 2021
Summary
Immunomodulatory drugs (IMiDs) like lenalidomide are crucial for treating multiple myeloma (MM). Combining IMiDs with monoclonal antibodies (MoAbs) like daratumumab enhances first-line MM therapy effectiveness.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Multiple myeloma (MM) management has seen significant therapeutic advancements.
- New drug classes, including proteasome inhibitors, immunomodulatory drugs (IMiDs), and monoclonal antibodies (MoAbs), have revolutionized MM treatment.
Purpose of the Study:
- To discuss the role of IMiDs (thalidomide, lenalidomide) in newly diagnosed MM.
- To highlight the mechanism of action of IMiDs and their application in first-line MM therapy.
- To present clinical data on enhancing IMiD-based regimens with MoAbs like daratumumab.
Main Methods:
- Literature review and database search (PubMed).
Main Results:
- Immunomodulation is integral to MM treatment at diagnosis and relapse.
- IMiD-based regimens, especially with MoAbs, demonstrate increased efficacy.
- Combination therapies like lenalidomide, dexamethasone, daratumumab, and bortezomib represent potent first-line MM treatments.
Conclusions:
- Understanding IMiD synergy with other agents can improve patient outcomes.
- Optimal first-line therapy is essential for the long-term benefit of all MM patients, regardless of age.
Keywords:
Anti-cd38immunomodulatory drugslenalidomidemonoclonal antibodymultiple myelomathalidomidetreatmentMore Related Videos
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