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Updated: Nov 12, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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[SARS-CoV-2 vaccines]

Thomas Lars Benfield1, Jannik Helweg-Larsen

  • 1thomas.lars.benfield@regionh.dk.

Ugeskrift for Laeger
|March 18, 2021
PubMed

Insights

Developing effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for controlling the COVID-19 pandemic. This review summarizes safety and efficacy data for various leading vaccine candidates nearing approval.

Area of Science:

  • Vaccinology
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, necessitates the development of safe and effective vaccines for global control.
  • Numerous vaccine candidates are undergoing development, with many in late-stage clinical trials.

Purpose of the Study:

  • To review and summarize the available safety and efficacy data for various types of SARS-CoV-2 vaccines.
  • To provide an overview of vaccines that are approved or nearing approval.

Main Methods:

  • Literature review of preclinical and clinical data for SARS-CoV-2 vaccines.
  • Focus on RNA-based, vector-based, inactivated whole-virus, and subunit vaccines.
  • Analysis of safety and efficacy data from Phase III trials.

Main Results:

  • Summary of safety profiles for different vaccine platforms.
  • Efficacy data presented for leading vaccine candidates.
  • Comparison of vaccine types nearing regulatory approval.

Conclusions:

  • Several vaccine types show promising safety and efficacy for controlling the COVID-19 pandemic.
  • The data supports the ongoing approval and deployment of diverse SARS-CoV-2 vaccines.
  • Vaccine development is critical for pandemic mitigation efforts.

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