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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Aortic arch calcification: a novel parameter for prediction of masked hypertension

Ertan Akbay1, Ali Çoner1, Sinan Akinci1

  • 1Department of Cardiology, Baskent University Hospital, Alanya Medical and Research Center, Alanya.

Blood Pressure Monitoring
|March 18, 2021
PubMed

Insights

Aortic arch calcification (AAC) can help diagnose masked hypertension, a condition linked to increased cardiovascular risk. This study found AAC more prevalent in masked hypertension patients, aiding its detection during office visits.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Diagnostic Imaging

Background:

  • Masked hypertension increases cardiovascular risks but is often underdiagnosed.
  • Aortic arch calcification (AAC) is a potential indicator for cardiovascular issues.

Purpose of the Study:

  • To investigate the role of aortic arch calcification (AAC) in diagnosing masked hypertension.
  • To assess AAC's utility in identifying patients with masked hypertension in clinical practice.

Main Methods:

  • Patients with office blood pressure (OBP) <140/90 mmHg underwent ambulatory blood pressure monitoring (ABPM).
  • Masked hypertension was defined per 2017 ACC/AHA guidelines (daytime BP ≥ 135/85 mmHg, nighttime BP ≥ 120/70 mmHg).
  • Aortic arch calcification (AAC) was assessed using direct X-ray telecardiography.

Main Results:

  • Of 216 participants, 50.9% had masked hypertension.
  • AAC was significantly more frequent in the masked hypertension group (44.5% vs. 26.4%, P = 0.005).
  • AAC showed a positive predictive value of 79% for masked hypertension in high-normal OBP individuals and 74% negative predictive value in normal OBP individuals.

Conclusions:

  • Aortic arch calcification (AAC) can serve as a valuable tool for predicting and excluding masked hypertension.
  • Integrating AAC assessment into routine office examinations may improve the diagnosis of masked hypertension.
Abstract

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