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Updated: Nov 12, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

MultiPhATE2: code for functional annotation and comparison of phage genomes.

Carol L Ecale Zhou¹, Jeffrey Kimbrel², Robert Edwards^3,4,5,6

¹Global Security Computing Applications, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

G3 (Bethesda, Md.)

|March 18, 2021

Summary

This summary is machine-generated.

We developed multiPhATE2, an enhanced tool for bacteriophage genome annotation and comparative genomics. This software improves gene finding, functional annotation, and comparative analysis, aiding researchers in studying viral genomes.

Keywords:

bacteriophage bioinformatics tool comparative genomics gene prediction genome annotation phage

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Area of Science:

Genomics
Bioinformatics
Microbiology

Background:

Bacteriophage genome analysis requires sophisticated tools for accurate annotation and comparison.
Existing tools may lack the comprehensive features needed for complex genomic studies.

Purpose of the Study:

To develop an advanced computational tool, multiPhATE2, for enhanced annotation and comparative genomics of bacteriophage genomes.
To extend the capabilities of the previous multiPhATE tool with improved gene finding and annotation functionalities.

Main Methods:

MultiPhATE2 integrates multiple gene-finding algorithms and compares their results.
It performs functional annotation of coding sequences using extended search algorithms and databases.
The tool facilitates gene matching across related bacteriophage genomes and utilizes multiprocessing for efficiency.

Main Results:

MultiPhATE2 provides improved accuracy and scope in bacteriophage genome annotation.
The software offers enhanced comparative genomics capabilities for closely related viral genomes.
It allows for user-defined adjustments and custom database integration, increasing flexibility.

Conclusions:

MultiPhATE2 is a powerful, flexible, and efficient tool for bacteriophage genome analysis.
It addresses the need for advanced computational resources in viral genomics research.
The tool supports researchers in advancing the understanding of bacteriophage diversity and function.