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Brain Imaging

Brain Imaging

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All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping.

Jung Min Lee¹, Dingchang Lin, Ha-Reem Kim¹

¹Department of Physics, Korea University, Seoul 02841, Republic of Korea.

|March 18, 2021

Summary

Researchers developed a novel tissue-like optoelectronic mesh for optogenetic neuromodulation and neural mapping. This device enables precise optical stimulation and neural signal recording, advancing brain circuit understanding and therapeutic applications.

Keywords:

biocompatible optogenetic probes chronic neural interface flexible waveguide injectable mesh electronics optogenetics

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Area of Science:

Neuroscience
Biomedical Engineering
Materials Science

Background:

Understanding neural circuits and treating brain disorders requires advanced tools for neural interfacing.
Existing optogenetic devices face challenges in biocompatibility and seamless brain integration.
Multifunctional devices capable of both neuromodulation and neural mapping are highly sought after.

Purpose of the Study:

To develop a biocompatible, tissue-like optoelectronic mesh for simultaneous optogenetic neuromodulation and neural mapping.
To achieve high spatial and temporal resolution in optical stimulation and neural activity sampling.
To create a device enabling chronic modulation of neural circuits and behavior studies.

Main Methods:

Fabrication of a flexible mesh integrated with SU-8 waveguides and electronics.
In vitro experiments in hydrogel to assess light propagation.
In vivo implantation in transgenic mice for neural signal recording.

Main Results:

Demonstrated efficient light propagation through integrated SU-8 waveguides in a freestanding mesh.
Successfully sampled optically evoked neural signals in vivo using the optoelectronic mesh.
The device exhibited a tissue-like nature, facilitating seamless brain interfacing.

Conclusions:

The developed tissue-like optoelectronic mesh is a promising multifunctional device for neuroscience research.
This technology can significantly aid in understanding neural circuits and developing therapeutic strategies for brain disorders.
The device supports chronic modulation and behavior studies, paving the way for biological and therapeutic applications.