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Updated: Nov 12, 2025

Author Spotlight: Investigating Early Events and Long-Term Effects of ACL Injuries for Osteoarthritis Progression
Published on: September 29, 2023
Medial Osteoarthritis in an ACL-Deficient Knee: A Critical Analysis Review
Sravya P Vajapey1, Paul M Alvarez, Nicholas J Greco
1Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, Ohio.
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In anterior cruciate ligament (ACL)-deficient knees, treatment of medial compartment osteoarthritis (OA) that is refractory to nonoperative modalities is a controversial subject.
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Currently available treatment options include unicompartmental knee arthroplasty (UKA) with or without ACL reconstruction (ACLR), high tibial osteotomy (HTO) with or without ACLR, and total knee arthroplasty (TKA).
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Each treatment option has its own risks and benefits, and the evidence that is reviewed in this article suggests that patient characteristics guide treatment selection.
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Future high-quality prospective studies that directly compare all 3 of the modalities are necessary to determine the best treatment option for different patient populations.
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