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Updated: Nov 12, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Intermittent fasting compromises the performance of eutrophic rats submitted to resistance training
Letícia Pereira Cavalcante1, Thiago da Rosa Lima2, Paula Caroline de Almeida1
1Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil.
Intermittent fasting (IF) impairs resistance training performance in rats. Combining IF with resistance training ladder climbs (RTLCs) increased stomach size and reduced food intake without affecting body weight.
Area of Science:
- Exercise Physiology
- Nutritional Science
- Animal Models
Background:
- Intermittent fasting (IF) is a popular dietary strategy with potential health benefits.
- The impact of IF on exercise performance, particularly resistance training, requires further investigation.
- Understanding these effects is crucial for optimizing training and nutritional plans.
Purpose of the Study:
- To analyze the effects of intermittent fasting (IF) on the performance of rats undergoing resistance training ladder climbs (RTLCs).
Main Methods:
- Thirty-two Wistar rats were divided into four groups: control, IF, trained control (TC), and trained intermittent fasting (TIF).
- The IF groups underwent 16-hour fasting daily.
- Training groups completed 6 weeks of RTLCs, with maximal load tests (MLT) conducted before and after the training period.
Main Results:
- Trained control rats exhibited the highest load-bearing capacity during the final MLT.
- Both TC and TIF groups showed significant improvements in MLT performance from pre- to post-training.
- The TIF group displayed a higher relative stomach weight and reduced food intake compared to control groups.
Conclusions:
- Intermittent fasting negatively impacted RTLC performance in rats.
- The combination of IF and RTLC led to increased relative stomach weight and decreased food intake, potentially indicating stomach dilation.
- These findings suggest that IF may not be optimal for enhancing resistance training outcomes.
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