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Early auditory-evoked potentials in body dysmorphic disorder: An ERP/sLORETA study.

Anastasios E Giannopoulos1, Ioanna Zioga2, Panos C Papageorgiou3

  • 1School of Electrical & Computer Engineering, National Technical University of Athens, Athens, Greece.

Psychiatry Research
|March 18, 2021
PubMed
Summary

Body dysmorphic disorder (BDD) patients show impaired attention, indicated by reduced early brain responses (N100). Lower N100 amplitude correlates with BDD severity, suggesting it as a potential biomarker.

Keywords:
Body Dysmorphic DisorderEEGN100 componentPrepulse InhibitionsLORETA

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Body dysmorphic disorder (BDD) involves preoccupation with perceived flaws and is linked to cognitive deficits, particularly in attention.
  • Understanding the neural underpinnings of attentional processing in BDD is crucial for developing effective interventions.

Purpose of the Study:

  • To investigate early neural responses, specifically N100 and P200 event-related potentials (ERPs), to auditory prepulse inhibition (PPI) and prepulse facilitation (PPF) in individuals with BDD.
  • To explore the relationship between these neural responses, attentional processing, and BDD severity.

Main Methods:

  • Fifty-five adults (30 with BDD, 25 healthy controls) participated in auditory PPI and PPF tasks.
  • Analysis involved global field power (GFP), ERPs, and source reconstruction to examine neural activity.
  • Comparisons were made between BDD patients and controls regarding N100 and P200 amplitudes and latencies.

Main Results:

  • BDD patients exhibited significantly reduced N100 amplitudes compared to controls in response to startle tones during both PPI and PPF paradigms.
  • Lower N100 GFP in BDD patients correlated positively with increased BDD symptom severity.
  • Source analysis revealed diminished neural activation in the N100 time window for BDD patients during PPI, with overall reduced scalp and source activations in PPI compared to PPF.

Conclusions:

  • The N100 ERP component may serve as an electrophysiological marker for BDD, potentially reflecting impaired attentional allocation.
  • Reduced N100 amplitude and its correlation with symptom severity offer insights into the pathophysiology of BDD.
  • ERPs combined with PPI/PPF protocols show promise for advancing the understanding and potential diagnosis of BDD.