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Interaction between non-coding RNAs and JNK in human disorders

Soudeh Ghafouri-Fard1, Atefe Abak2, Mahdi Mohaqiq3

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 18, 2021
PubMed

Insights

The Jun N-terminal Kinase (JNK) pathway, involving microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), plays a critical role in human diseases. Understanding this JNK-miRNA/lncRNA interaction is key to developing new therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Genetics

Background:

  • The Jun N-terminal Kinase (JNK) signaling pathway is crucial for cellular processes like gene expression, cytoskeletal organization, and apoptosis.
  • JNK signaling is implicated in both normal development and disease, including cancer and inflammatory disorders.
  • MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are known regulators of gene expression and have functional links to JNK pathways.

Purpose of the Study:

  • To review the functional interactions between JNK signaling pathways and regulatory RNAs (miRNAs and lncRNAs).
  • To elucidate the role of these JNK-miRNA/lncRNA interactions in the pathobiology of various human disorders.
  • To highlight the contribution of these interactions to both non-malignant and malignant conditions.

Main Methods:

  • Literature review of studies investigating JNK signaling, miRNAs, and lncRNAs.
  • Analysis of research on the involvement of JNK-related regulatory RNAs in disease pathogenesis.
  • Synthesis of findings on the role of these interactions in human disorders.

Main Results:

  • JNK signaling pathways are intricately connected with specific miRNAs and lncRNAs.
  • These interactions are implicated in the pathogenesis of diverse conditions, including traumatic brain injury, inflammatory diseases, and cardiovascular events.
  • JNK-associated miRNAs and lncRNAs are significantly involved in the development and progression of various cancers, such as lung, liver, and colon cancer.

Conclusions:

  • The interplay between JNK signaling and regulatory RNAs (miRNAs/lncRNAs) is a significant factor in human disease.
  • Targeting these interactions presents a potential therapeutic avenue for managing a range of disorders, including cancers.
  • Further research into JNK-miRNA/lncRNA mechanisms can lead to novel diagnostic and therapeutic strategies.
Keywords:
CancerJNK pathwayLncRNAMiRNA

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