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Updated: Nov 12, 2025
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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[Embolic stroke of undetermined source (ESUS) - Classification of a new stroke entity]
Alkisti Kitsiou1, Frédéric Zuhorn1, Rolf Wachter2
1Evangelisches Klinikum Bethel, Klinik für Neurologie, Bielefeld, Deutschland.
Deutsche Medizinische Wochenschrift (1946)
|March 18, 2021
Summary
Embolic stroke of undetermined source (ESUS) is a type of cryptogenic stroke. Further diagnostics can help identify specific causes, reducing the number of undetermined strokes.
Area of Science:
- Neurology
- Cardiology
- Vascular Medicine
Background:
- Embolic stroke of undetermined source (ESUS) is a significant clinical challenge.
- ESUS represents a subset of cryptogenic strokes with an embolic pattern on imaging.
- Current diagnostic evaluations often fail to identify a specific etiology.
Purpose of the Study:
- To analyze the fundamental concept of ESUS.
- To review recent evidence from cohort studies on ESUS.
- To reassess the definition, etiology, and diagnostic approaches for ESUS.
Main Methods:
- Literature review of recent cohort studies.
- Analysis of the ESUS definition and diagnostic criteria.
- Reassessment of etiological factors and diagnostic strategies.
Main Results:
- ESUS is characterized by an embolic stroke pattern without an identified cause after thorough evaluation.
- Recent cohort studies provide insights into the characteristics and outcomes of ESUS patients.
- Targeted diagnostic interventions can potentially uncover specific stroke etiologies in a subset of ESUS cases.
Conclusions:
- Refining the definition and diagnostic pathways for ESUS is crucial.
- Implementing targeted diagnostics can decrease the overall burden of cryptogenic strokes.
- Identifying specific causes in ESUS patients improves stroke management and prevention strategies.
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