Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.4K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.4K
Neuronal Communication01:28

Neuronal Communication

2.3K
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
2.3K
Integration of Synaptic Events01:28

Integration of Synaptic Events

2.8K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma signals of lung tumor promotion for molecular cancer prevention.

Cell·2026
Same author

Modulation of the excitation/inhibition balance by astrocytes in a tripartite synapse model of Alzheimer's disease.

Neural regeneration research·2026
Same author

Synolitic Graph Neural Networks for MRI-Derived Radiomic-Based Prediction of Prostate Cancer Progression on Active Surveillance.

Cancers·2026
Same author

Sex-Stratified Machine Learning for the Prediction of Post-COVID Condition: A Longitudinal Cohort Study.

Journal of clinical medicine·2026
Same author

Sparsity-induced resonance in complex networks.

Physical review. E·2026
Same author

Prediction of preterm birth using 3D volume cesarean scar morphology in pregnant women with previous advanced labor cesarean delivery.

Acta obstetricia et gynecologica Scandinavica·2026
Same journal

Erratum: Low-dimensional model for adaptive networks of spiking neurons [Phys. Rev. E 111, 014422 (2025)].

Physical review. E·2026
Same journal

Disentangling the effects of many-body forces on depletion interactions.

Physical review. E·2026
Same journal

Charge transport and mode transition in dual-energy electron beam diodes.

Physical review. E·2026
Same journal

Optimization of multisite reactions in complex compartmentalized media.

Physical review. E·2026
Same journal

Origin of geometric cohesion in nonconvex granular materials: Interplay between interdigitation and rotational constraints enhancing frictional stability.

Physical review. E·2026
Same journal

Interaction of walkers with a standing Faraday wave.

Physical review. E·2026
See all related articles

Related Experiment Video

Updated: Nov 12, 2025

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.1K

Estimating integrated information in bidirectional neuron-astrocyte communication.

Luis Abrego1, Susanna Gordleeva2,3, Oleg Kanakov3

  • 1Department of Mathematics, University College London, London, United Kingdom.

Physical Review. E
|March 19, 2021
PubMed
Summary
This summary is machine-generated.

Astrocytes play a crucial role in neural information processing by modulating synaptic transmission. This study reveals how astrocyte feedback enhances neural communication synergy, optimizing information integration in neuronal networks.

More Related Videos

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
16:38

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

27.7K
The Indirect Neuron-astrocyte Coculture Assay: An In Vitro Set-up for the Detailed Investigation of Neuron-glia Interactions
11:08

The Indirect Neuron-astrocyte Coculture Assay: An In Vitro Set-up for the Detailed Investigation of Neuron-glia Interactions

Published on: November 14, 2016

15.1K

Related Experiment Videos

Last Updated: Nov 12, 2025

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.1K
Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
16:38

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices

Published on: November 26, 2012

27.7K
The Indirect Neuron-astrocyte Coculture Assay: An In Vitro Set-up for the Detailed Investigation of Neuron-glia Interactions
11:08

The Indirect Neuron-astrocyte Coculture Assay: An In Vitro Set-up for the Detailed Investigation of Neuron-glia Interactions

Published on: November 14, 2016

15.1K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Astrocyte Biology

Background:

  • Astrocytes are increasingly recognized for their role in neural information processing.
  • Their modulation of synaptic transmission impacts how neurons communicate.
  • Understanding astrocyte influence on information integration over time is critical.

Purpose of the Study:

  • To investigate the role of astrocytes in information integration within neuronal ensembles.
  • To quantify the impact of astrocytes on information carried by compound neuronal events.
  • To explore the mechanisms of bidirectional communication between astrocytes and neurons.

Main Methods:

  • Development of a computational model simulating bidirectional communication between astrocytes and neurons.
  • Modeling glutamate-induced calcium signaling pathways.
  • Measurement of "integrated information" to assess information processing.
  • Analysis using net synergy and mutual information.

Main Results:

  • Astrocytes dynamically coordinate neural activity, influencing information processing.
  • Astrocytic feedback promotes synergistic interactions in neural communication.
  • Maximal synergy is achieved with a balance between neural correlation and spontaneous activity.
  • Astrocytes exhibit integrative properties in neuronal communication.

Conclusions:

  • Astrocytes are integral components of neural information processing.
  • Bidirectional astrocyte-neuron communication, mediated by calcium signaling, is key.
  • Astrocytic feedback enhances network synergy and information integration.
  • A balanced neural activity state maximizes the beneficial effects of astrocytes.