Related Experiment Video
Updated: Nov 12, 2025
05:42
Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation
Published on: April 5, 2024
1.2K
Visible-light-induced hyaluronate hydrogel for soft tissue fillers
Bo Min Hong1, Hee Cheol Kim1, Jae Eun Jeong2
1Department of Organic Materials Engineering, Chungnam National University, Daejeon 34134, South Korea.
International Journal of Biological Macromolecules
|March 19, 2021
Summary
This study introduces tyramine-modified hyaluronic acid (HA-Tyr) as a novel photocrosslinked filler. This injectable HA-Tyr microgel offers improved properties and safety, presenting a promising alternative to current dermal fillers.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Dermatology
Background:
- Hyaluronic acid (HA) is a common dermal filler due to its biocompatibility.
- Current HA fillers may cause side effects from residual chemical crosslinking agents.
Purpose of the Study:
- To develop a safer, photocrosslinkable hyaluronic acid filler.
- To create an injectable microgel filler with enhanced properties.
Main Methods:
- Tyramine (Tyr) was grafted onto HA to create HA-Tyr.
- Photocrosslinked HA-Tyr hydrogels were formed using a vitamin B2 derivative photoinitiator.
- Hydrogels were converted into injectable microgels for filler application.
Main Results:
- Crosslinking density and mechanical strength increased with irradiation time.
- The HA-Tyr microgel demonstrated excellent elastic recovery and injectability.
- Non-cytotoxicity and positive fibroblast proliferation were observed.
Conclusions:
- Photocrosslinked HA-Tyr hydrogels are a viable alternative to commercial dermal fillers.
- This approach offers improved safety by avoiding chemical crosslinking agents.
