Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

High-Performance Liquid Chromatography: Types of Detectors01:15

High-Performance Liquid Chromatography: Types of Detectors

1.2K
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simple, Affordable Distance-Based Paper Analytical Device for the Quantitative Perfluorooctane Sulfonate Detection in Drinking Water and Beverage Samples.

ACS sensors·2026
Same author

Acceptor-phase-free gel electromembrane extraction integrated with smartphone colorimetry for the quantification of cephalexin in pharmaceutical and environmental water samples.

Talanta·2026
Same author

Comparative Effectiveness of Renin-Angiotensin System Inhibitors in Heart Failure With Nonreduced Ejection Fraction: A Multicenter Cohort Study.

Journal of cardiovascular pharmacology and therapeutics·2026
Same author

A simple photothermal paper-based analytical device using silver nanomaterials for quantitative mercury ion monitoring in drinking water and Wolffia samples.

The Analyst·2026
Same author

Hydrogen-Bond Topology Governs Clustering-Triggered Emission in Non-Conjugated Small Molecules.

The journal of physical chemistry. B·2026
Same author

A pilot study of assessing visual hallucinations using virtual reality in lewy body disorders.

Scientific reports·2026

Related Experiment Video

Updated: Nov 12, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

16.0K

Highly sensitive distance-based liquid crystalline visualization for paper-based analytical devices.

Kawin Khachornsakkul1, Jung-Jung Chang2, Ping-Heng Lin2

  • 1Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Prachautid Road, Thungkru, Bangkok, 10140, Thailand.

Analytica Chimica Acta
|March 19, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a novel paper-based sensor using liquid crystals for sensitive, distance-based detection of biomarkers like bilirubin. The simple, instrument-free device offers accurate results for early disease diagnosis.

Keywords:
BilirubinDistance-based sensorsLiquid crystalPaper-based sensorsUltrasound

More Related Videos

Orientational Transition in a Liquid Crystal Triggered by the Thermodynamic Growth of Interfacial Wetting Sheets
06:26

Orientational Transition in a Liquid Crystal Triggered by the Thermodynamic Growth of Interfacial Wetting Sheets

Published on: May 15, 2017

7.4K
Iridium Oxide-reduced Graphene Oxide Nanohybrid Thin Film Modified Screen-printed Electrodes as Disposable Electrochemical Paper Microfluidic pH Sensors
09:15

Iridium Oxide-reduced Graphene Oxide Nanohybrid Thin Film Modified Screen-printed Electrodes as Disposable Electrochemical Paper Microfluidic pH Sensors

Published on: November 22, 2016

10.8K

Related Experiment Videos

Last Updated: Nov 12, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

16.0K
Orientational Transition in a Liquid Crystal Triggered by the Thermodynamic Growth of Interfacial Wetting Sheets
06:26

Orientational Transition in a Liquid Crystal Triggered by the Thermodynamic Growth of Interfacial Wetting Sheets

Published on: May 15, 2017

7.4K
Iridium Oxide-reduced Graphene Oxide Nanohybrid Thin Film Modified Screen-printed Electrodes as Disposable Electrochemical Paper Microfluidic pH Sensors
09:15

Iridium Oxide-reduced Graphene Oxide Nanohybrid Thin Film Modified Screen-printed Electrodes as Disposable Electrochemical Paper Microfluidic pH Sensors

Published on: November 22, 2016

10.8K

Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Paper-based analytical devices (PADs) offer low-cost, portable sensing solutions.
  • Liquid crystals (LCs) exhibit unique optical properties sensitive to environmental changes.
  • Sensitive detection of biomarkers is crucial for early disease diagnosis.

Purpose of the Study:

  • To develop a highly sensitive, distance-based liquid crystalline visualization method for PADs.
  • To demonstrate the utility of this sensor for quantifying bilirubin in biological samples.
  • To establish a simple, instrument-free method for biomarker detection.

Main Methods:

  • Immobilization of 4-cyano-4'-pentylbiphenyl (5CB) liquid crystals onto paper strips.
  • Ultrasound-assisted decomposition of 5CB by hydroxyl radicals generated from oxidase enzymatic reactions.
  • Visual quantification of analyte concentration by measuring color change length on the paper strip.

Main Results:

  • The paper sensor achieved a linear detection range for bilirubin (BR) from 2.0 to 30.0 pmol/L.
  • A low limit of detection (LOD) of 0.80 pmol/L for BR was obtained.
  • High reproducibility (RSD < 3.50%) and accuracy (99.09-107.89% recovery) were demonstrated in biological samples.

Conclusions:

  • This work presents the first demonstration of a distance-based LC visualization for PADs.
  • The developed sensor enables sensitive, instrument-free quantification of biomarkers like BR at picomolar levels.
  • This approach holds potential for quantitative analysis of other oxidase-based biomarkers for disease diagnosis.