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Updated: Nov 12, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Disseminated Intravascular Coagulation
1National Institutes of Health, Bethesda, MD.
Objectives:
This article describes the pathophysiology and causes of disseminated intravascular coagulation (DIC). Implications for nurses are also reviewed.
Data Sources:
Pee-reviewed articles and up-to-date references were used to check accuracy of the information and provide information for current management of this syndrome.
Conclusion:
DIC is an oncologic emergency in which bleeding and clotting occur simultaneously. In the cancer population, the syndrome is frequently associated with certain malignancies or sepsis. If not recognized and treated early, mortality can be high. This article describes the risk factors that contribute to DIC, clinical manifestations of DIC, and its treatment.
Implications For Nursing Practice:
Nurses need to consider the presenting diagnosis of the patient and understand laboratory abnormalities that signify DIC. The nurse plays a key role in early recognition of this syndrome as prompt treatment can reduce fatality.
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