Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

11.0K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
11.0K
Amyloid Fibrils03:03

Amyloid Fibrils

6.1K
6.1K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunohistochemical Expression of CK13 and Molecular Analysis of KRT13 and APC in Odontogenic Ghost Cell Lesions, Adenoid Ameloblastoma, and Conventional Ameloblastoma.

Head and neck pathology·2026
Same author

Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in 14 Latin American Cases.

Head and neck pathology·2026
Same author

Oral manifestations of anaplastic large cell lymphoma: clinicopathological features and main immunophenotypic findings of 3 cases.

Journal of hematopathology·2026
Same author

Solitary Nodule in the Hard Palate.

Oral diseases·2026
Same author

Intraductal papillary mucinous neoplasm on the lower lip: Letter to editor of a rare entity.

Oral oncology·2026
Same author

COVID-19 vaccination and immunoreactant deposition in non-autoimmune oral mucosal pathologies.

Oral surgery, oral medicine, oral pathology and oral radiology·2026

Related Experiment Video

Updated: Nov 12, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
10:04

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

13.7K

Oral lesions containing amyloid-like material.

Carla Isabelly Rodrigues-Fernandes1, Cinthia Bardález López de Cáceres1, Maria Sissa Pereira Sant'Ana2

  • 1Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
|March 19, 2021
PubMed
Summary

Oral pathology often encounters amyloid-like materials that mimic true amyloid. This review details conditions with similar histologic features, aiding accurate diagnosis of oral and perioral diseases.

More Related Videos

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

10.9K
Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

55.7K

Related Experiment Videos

Last Updated: Nov 12, 2025

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
10:04

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging

Published on: October 20, 2017

13.7K
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

10.9K
Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

55.7K

Area of Science:

  • Oral Pathology
  • Histopathology
  • Diagnostic challenges in dentistry

Background:

  • True amyloid is found in oral amyloidosis and odontogenic tumors.
  • Histologic examination can reveal amyloid-like substances in various oral and perioral diseases.
  • These include collagenous sclerosis, fibrin, degenerated elastic fibers, and dentinoid material.

Purpose of the Study:

  • To review clinicopathologic features of oral and perioral diseases presenting with amyloid-like material.
  • To highlight diagnostic challenges due to histologic similarities.
  • To emphasize the need for comprehensive diagnostic approaches.

Main Methods:

  • Literature review of oral and perioral conditions with amyloid-like deposits.
  • Analysis of clinicopathologic features and diagnostic modalities.
  • Comparison of true amyloid with amyloid-like substances.

Main Results:

  • Several oral and perioral conditions exhibit amyloid-like materials that resemble true amyloid.
  • Histologic similarity can lead to diagnostic confusion.
  • Accurate diagnosis requires integrating clinical, laboratory, and specialized histochemical/immunohistochemical findings.

Conclusions:

  • Distinguishing true amyloid from amyloid-like materials is crucial in oral pathology.
  • A multidisciplinary diagnostic approach is essential for accurate identification and patient management.
  • Understanding these entities improves diagnostic accuracy for oral and perioral lesions.