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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

A systematic review of Antimicrobial Stewardship Program implementation in Middle Eastern countries.

Mera A Ababneh¹, Sara A Nasser¹, Abeer M Rababa'h¹

¹Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases

|March 19, 2021

Summary

Antimicrobial Stewardship Programs (ASPs) in the Middle East show positive clinical effects, improving antibiotic susceptibility and reducing use. More data and investment are needed to expand these vital global health initiatives.

Keywords:

Antimicrobial Stewardship Program Antimicrobial use Bacterial resistance Middle East Practices

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Published on: October 24, 2019

Area of Science:

Infectious Diseases
Public Health
Healthcare Management

Background:

Antimicrobial resistance poses a significant global health threat.
Antimicrobial Stewardship Programs (ASPs) are crucial for combating resistance.
This review focuses on ASP practices within Middle Eastern healthcare systems.

Purpose of the Study:

To evaluate and synthesize published Antimicrobial Stewardship Program practices in Middle Eastern countries.
To identify trends and outcomes associated with ASP implementation in the region.

Main Methods:

A systematic literature search was conducted across major electronic databases (PubMed/MEDLINE, Embase, EBSCO, Cochrane Library, Google Scholar).
Studies published between January 2005 and December 2020 assessing ASP practices in Middle Eastern countries were included.
PRISMA guidelines were followed to ensure systematic review integrity.

Main Results:

Twenty studies met the inclusion criteria, with a notable concentration in Saudi Arabia and Qatar.
Reported ASP interventions included prospective auditing, pre-authorization, antibiotic restriction, and education.
Implemented ASPs demonstrated a correlation with enhanced antimicrobial susceptibility rates and reduced overall antimicrobial consumption.

Conclusions:

There is a noted scarcity of published data on ASP practices in the Middle East.
The adoption of ASPs in Middle Eastern hospitals has yielded favorable clinical outcomes.
Policymakers and stakeholders should prioritize investment in and promotion of ASPs as essential healthcare system components.