Diffuse encephalitic toxoplasmosis in HIV
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Updated: Nov 12, 2025

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
Published on: December 9, 2014
Jasmine Pearce1, Ray Sheridan2, Johnathan Shaw3
1Department of General Medicine, Royal Devon and Exeter Hospital, Exeter, UK jasmine.pearce1@nhs.net.
Abstract:
This case demonstrates an atypical radiological presentation of cerebral toxoplasmosis in a 62-year-old HIV-positive patient. The diagnosis is discussed alongside MRI imaging, laboratory results and treatment. Central nervous system toxoplasmosis is typically associated with ring enhancing lesions on neuroimaging with contrast, but the radiology for this patient shows diffuse white matter changes and ependymal enhancement, which would normally suggest an alternative diagnosis.
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