Related Experiment Video
Updated: Nov 12, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
COVID-19-induced granulomatosis with polyangiitis
Vijairam Selvaraj1,2, Abdelmoniem Moustafa3,2, Kwame Dapaah-Afriyie3,2
1Hospital Medicine, Miriam Hospital, Providence, Rhode Island, USA vijairam.selvaraj@lifespan.org.
This case report highlights the diagnostic challenge differentiating COVID-19 from granulomatosis with polyangiitis due to overlapping symptoms. A patient initially diagnosed with COVID-19 later developed symptoms indicative of granulomatosis with polyangiitis.
Area of Science:
- Internal Medicine
- Rheumatology
- Infectious Diseases
Background:
- COVID-19 and granulomatosis with polyangiitis (GPA) present with similar clinical and radiological findings.
- Distinguishing between these conditions can be diagnostically challenging for physicians.
Observation:
- A patient diagnosed with COVID-19 in October 2020 experienced persistent fatigue, dyspnea, and anemia one month later.
- Worsening renal function was noted, prompting further investigation.
Findings:
- Elevated antineutrophil cytoplasmic antibodies (ANCA) and antiproteinase 3 (PR3) antibodies were detected.
- The patient was subsequently diagnosed with granulomatosis with polyangiitis.
Implications:
- This case underscores the importance of considering GPA in patients with persistent or worsening symptoms post-COVID-19.
- Awareness of overlapping features is crucial for accurate diagnosis and timely management of both conditions.
Related Concept Videos
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

