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Updated: Sep 10, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
[An application of a new antibiotic, ceftriaxone, during the perinatal period]
1Department of Obstetrics and Gynecology, Toyama Prefectural Central Hospital.
Abstract:
1. Ceftriaxone (CTRX) was not transferred well into cerebrospinal fluid in healthy individuals. 2. The transplacental passage and the transfer of CTRX into amniotic fluid were very good, and CTRX seems useful for the treatment of perinatal infections. 3. Clinically, CTRX was very effective against amniotic infections and infections of the puerperal uterus: Clinical efficacies were excellent in 1 case and good in 3 out of 4 cases (efficacy rate: 100%). 4. No side effects or laboratory abnormalities were observed.
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