Levofloxacin-Induced Acute Pancreatitis.

Area of Science:

• Internal Medicine
• Gastroenterology
• Pharmacology

Background:

• Drug-induced pancreatitis is a rare cause of acute pancreatitis (AP), accounting for less than 2% of cases.
• Quinolones are frequently prescribed antimicrobials, with sporadic reports linking them to pancreatitis.

Observation:

• A 74-year-old male developed fever, severe abdominal pain, and nausea two days after starting levofloxacin (LVF) for acute cystitis.
• Initial laboratory tests showed leukocytosis, elevated C-reactive protein, amylase, and lipase.
• Abdominal ultrasound revealed pancreatic head inflammation consistent with AP.

Findings:

• The patient was diagnosed with acute pancreatitis.
• Discontinuation of levofloxacin and supportive care led to complete symptom resolution.
• No other causes for acute pancreatitis were identified.

Implications:

• Levofloxacin-induced pancreatitis, though uncommon, should be considered in patients with acute pancreatitis.
• Enhanced physician awareness is crucial for the timely diagnosis and management of this adverse drug reaction.